by Researchers from the University of Minnesota Medical School have made a groundbreaking discovery, identifying a new pathway that could be instrumental in combating cardiovascular disease. The findings of their study, which was recently published in Nature Cardiovascular Research, have significant implications for future treatments.
The research team focused on a molecule called TREM2 and its potential therapeutic role in treating atherosclerosis. Atherosclerosis occurs when plaque accumulates inside arteries, and it is a leading cause of cardiovascular diseases. According to the Centers for Disease Control and Prevention, these diseases are the primary cause of death and disability worldwide.
Using preclinical models of atherosclerosis, the team found that deleting the TREM2 gene in macrophages, which are critical components of the immune system, led to a remarkable inhibition of the disease progression. Moreover, targeted deletion of the TREM2 pathway showed promise in reducing pre-existing atherosclerotic disease. This strongly suggests that TREM2 could serve as a valuable immunotherapeutic target for future studies on cardiovascular disease risk.
Continuing their research, the team has partnered with Alector, Inc., a pharmaceutical company specializing in innovative therapies. Together, they plan to conduct preclinical testing of antibodies that target TREM2. The aim is to develop effective strategies to halt the progression of atherosclerosis and potentially revolutionize the treatment of cardiovascular diseases.
The research project received funding from esteemed organizations, including the American Heart Association, National Institute of Allergy and Infectious Diseases, and the Minnesota Office of Higher Education. With their support, the study has the necessary resources to advance and make a lasting impact on the fight against cardiovascular disease.
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1. Source: Coherent Market Insights, Public sources, Desk research
2. We have leveraged AI tools to mine information and compile it
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