July 19, 2024
Anti-Neprilysin Market Growth

The increasing R&D focus on NEP inhibition is anticipated to open up new avenues for the Anti-Neprilysin market

The Anti-Neprilysin Market is estimated to be valued at US$ 1,263.3 Mn in 2023 and is expected to exhibit a CAGR of 4.6% over the forecast period 2023 to 2030, as highlighted in a new report published by Coherent Market Insights.

Market Overview:

Anti-Neprilysins are drugs that act by inhibiting neprilysin, which is an enzyme that breaks down natriuretic peptides responsible for sodium and water excretion by the kidneys. They are widely used for the treatment of congestive heart failure. Some key anti-neprilysin products include sacubitril/valsartan combination (Entresto) from Novartis AG, which acts as an angiotensin receptor-neprilysin inhibitor (ARNi).

Market Dynamics:

Increasing prevalence of congestive heart failure is expected to propel the anti-neprilysin market growth over the forecast period. For instance, according to the American Heart Association’s Heart Disease and Stroke Statistics- 2022 Update Report, over 6 million American adults aged 20 and older suffer from heart failure, with the condition more prevalent among older adults. Out of these, approximately half of people who develop heart failure die within 5 years of diagnosis. Growing geriatric population prone to developing heart failure is thus expected to boost demand for anti-neprilysin drugs.

Secondly, favorable clinical trial results and regulatory approvals for new anti-neprilysin drugs such as Entresto are also anticipated to drive the market. Entresto demonstrated significant reduction in cardiovascular deaths and hospitalization for heart failure in phase 3 clinical trials. Its approval for indication expansion to treat patients with symptomatic heart failure with preserved ejection fraction (HFpEF) is expected to expand the eligible patient pool.

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Segment Analysis

The global anti-Neprilysin market is dominated by the cardiovascular segment. This segment accounts for over 60% of the total market share owing to the high efficacy of Neprilysin inhibitors in the treatment of various cardiovascular diseases like heart failure with reduced ejection fraction. Within the cardiovascular segment, drugs indicated for heart failure treatment form the largest sub-segment.

PEST Analysis

Political: Regulatory bodies like the FDA are increasing fast-track approvals and priority reviews for novel candidates targeting unmet clinical needs. This encourages R&D in the market.

Economic: Growing geriatric population and rising healthcare spending in developing nations are fueling market growth. However, high R&D costs associated with drug development pose challenges.

Social: Increasing awareness about heart conditions and their management is driving patients to seek efficient treatment options.

Technological: Advancements in drug delivery systems and analytical technologies are expediting clinical research and aiding the development of effective anti-Neprilysin therapies.

Key Takeaways

The global anti-Neprilysin market is expected to witness high growth, exhibiting CAGR of 4.6% over the forecast period, due to increasing incidence of cardiovascular diseases. The market was valued at US$ 1,263.3 Mn in 2023 and is anticipated to reach US$ 1,800 Mn by 2030.

North America currently dominates the market owing to rising public health awareness initiatives by governments and high healthcare expenditure. Europe follows poised to grow at a steady pace due to large patient base and favorable reimbursement scenario.

Key players operating in the anti-Neprilysin market are BIOPROJET, Novartis AG, Pharmaleads SA, Theravance Biopharm, Cipla Inc, and Oceanic Pharmachem Pvt. Ltd. BIOPROJET leads the market with product offerings for treatment of heart failure. Novartis AG closely follows with blockbuster candidates in pipeline for cardiovascular therapies.

1. Source: Coherent Market Insights, Public sources, Desk research
2. We have leveraged AI tools to mine information and compile it